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![]() We also look at a number of other factors, like road quality. If we predict that traffic is likely to become heavy in one direction, we’ll automatically find you a lower-traffic alternative. Our predictive traffic models are also a key part of how Google Maps determines driving routes. To account for this sudden change, we’ve recently updated our models to become more agile-automatically prioritizing historical traffic patterns from the last two to four weeks, and deprioritizing patterns from any time before that. Since then, parts of the world have reopened gradually, while others maintain restrictions. We saw up to a 50 percent decrease in worldwide traffic when lockdowns started in early 2020. Since the start of the COVID-19 pandemic, traffic patterns around the globe have shifted dramatically. This technique is what enables Google Maps to better predict whether or not you’ll be affected by a slowdown that may not have even started yet!įor most of the 13 years that Google Maps has provided traffic data, historical traffic patterns have been reliable indicators of what your conditions on the road could look like-but that's not always the case. ![]() By partnering with DeepMind, we’ve been able to cut the percentage of inaccurate ETAs even further by using a machine learning architecture known as Graph Neural Networks–with significant improvements in places like Berlin, Jakarta, São Paulo, Sydney, Tokyo, and Washington D.C. Our ETA predictions already have a very high accuracy bar–in fact, we see that our predictions have been consistently accurate for over 97% of trips. Recently, we partnered with DeepMind, an Alphabet AI research lab, to improve the accuracy of our traffic prediction capabilities. We then combine this database of historical traffic patterns with live traffic conditions, using machine learning to generate predictions based on both sets of data. For example, one pattern may show that the 280 freeway in Northern California typically has vehicles traveling at a speed of 65mph between 6-7am, but only at 15-20mph in the late afternoon. To predict what traffic will look like in the near future, Google Maps analyzes historical traffic patterns for roads over time. Predicting traffic with advanced machine learning techniques, and a little bit of history This is where technology really comes into play. ![]() But while this information helps you find current traffic estimates -whether or not a traffic jam will affect your drive right now-it doesn’t account for what traffic will look like 10, 20, or even 50 minutes into your journey. When people navigate with Google Maps, aggregate location data can be used to understand traffic conditions on roads all over the world. Live traffic, powered by drivers all around the world If you’ve ever wondered just how Google Maps knows when there’s a massive traffic jam or how we determine the best route for a trip, read on. Today, we’ll break down one of our favorite topics: traffic and routing. While all of this appears simple, there’s a ton going on behind the scenes to deliver this information in a matter of seconds. When you hop in your car or on your motorbike and start navigating, you’re instantly shown a few things: which way to go, whether the traffic along your route is heavy or light, an estimated travel time, and an estimated time of arrival (ETA). Every day, over 1 billion kilometers are driven with Google Maps in more than 220 countries and territories around the world. ![]() The cell wall components of fungi can represent a considerable part (up to 40–50%) of their body weight. Based on Fesel and Zuccaro’s model, the chitin layer is located in the cell membrane, while the middle position includes the glucan molecules (α- and β-glucans), and the outermost layer consists of mannoproteins. According to Grün’s model, the cell wall contains different glucans (α- and β-glucans), glycoproteins, and chitin. ![]() The focus of interest is on the cell wall structure of large fungi the “mushroom” category essentially refers to Ascomycetes and Basidiomycetes (the taxa with fruiting bodies). ![]() A newer understanding of the systems of the fungal world (according to which fungi and mushroom-like organisms belong to Protista, Chromista, or Eumycota kingdoms) indicates that the cell wall components of each group are typically different (e.g., cellulose is not a component of the cell wall of Eukaryota fungi). The problem of understanding cell wall composition and structure has been an important mycological question for decades. The cell wall has a role in permeability, in the movement of intracellular enzymes into the environment, and in the uptake of hydrolyzed metabolites from nature. The wall is a very important organelle of fungal cells, having different vital functions: it is responsible for mechanical protection, osmotic conditions, protection from dehydration, binding of distinct molecules, etc. Nowadays, mushrooms (both wild and cultivated taxa) have a dual role, since on the one hand they are increasingly important and valuable foods, and on the other hand, they are sources of active substances of increasing importance (i.e., molecules with biological activity). More and more research and measurement data are being published on the composition and different constituents of mushrooms. This review presents in more detail the glucans of lentinan (from Lentinula edodes), pleuran (from Pleurotus ostreatus), grifolan (from Grifola frondose), schizophyllan (from Schizophyllum commune), and krestin (from Trametes versicolor), along with their main biological effects. The glucan levels of individual fungal taxa (including varieties) differ quantitatively and qualitatively. The glucan contents of the stipe exceed the values of the caps. The biological effect of β-glucan molecules is proportional to the integrity of the tertiary structure. Congo red dye reacts with the tertiary triple helix structure, and the resulting glucan content better reflects the biological value of glucan molecules. True comparisons can only be made using the same method. The two methods used today for glucan determination are the enzymatic and Congo red methods. The biosynthesis of glucans takes place in the cytoplasm, the processes of initiation and then chain extension take place with the help of the glucan synthase enzyme complex (EC 2.4.1.34), and the sugar units are provided by sugar donor UDPG molecules. Different glucans can be isolated from different mushroom species, and several glucan fractions can be obtained. It seems that the existence and integrity of the triple helix structure are criteria for their biological effects. X-ray diffraction studies were the first to determine the triple helix configuration of some glucans. Their molecular weights range from 10 4 to 10 5 Da, and rarely 10 6 Da. Glucans from mushrooms are polysaccharides that contain sugar chains, sometimes of only one kind (glucose), sometimes having several monosaccharide units, and they have two (α and β) anomeric forms (isomers). At the end of the 19th century, but mainly since the middle of the 20th century, progressively more scientific information has been published. Folk medicine (especially in the Far East) used medicinal mushrooms based on previous experience. In addition to the beneficial nutritional properties of mushrooms (mineral elements, favorable proteins, low fat and energy content, pleasant aroma, and flavor), they have a high glucan content. Among these, the homo- or heteropolymeric glucan molecules are decisive, as they not only protect fungal cells but also have broad, positive biological effects on the animal and human bodies. Carbohydrates, including polysaccharide macromolecules, are the main constituents of the fungal cell wall. ![]() PDPK1 is a 556 amino acid residue long polypeptide with two domains (i.e., the kinase and the Preckstrin homology (PH) domain). The findings show that the newly discovered 11-Hydroxytephrosin and Torosaflavone A bind to PDPK1 in an ATP-competitive manner, suggesting that they could one day be used as therapeutic scaffolds against PDPK1-associated diseases including cancer. The simulation results revealed that PDPK1 forms stable docked complexes with the elucidated compounds. The conformational dynamics and complex stability of PDPK1 with the selected compounds were then studied using interaction analysis and molecular dynamics (MD) simulations for 100 ns. ![]() These compounds preferentially bind to the ATP-binding pocket of PDPK1 and interact with functionally significant residues. Both compounds showed drug-likeness as predicted by the ADMET analysis and their physicochemical parameters. ![]() Finally, we identified two natural compounds, 11-Hydroxytephrosin and Torosaflavone A, bearing substantial affinity with PDPK1. Primarily, the Lipinski rules, ADMET, and PAINS filter were applied and then the binding affinities, docking scores, and selectivity were carried out to find effective hits against PDPK1. In this work, we conducted a systematic virtual screening of natural compounds from the IMPPAT database to identify possible PDPK1 inhibitors. Prices and configurations may vary.The 3-phosphoinositide-dependent protein kinase 1 (PDPK1) has a significant role in cancer progression and metastasis as well as other inflammatory disorders, and has been proposed as a promising therapeutic target for several malignancies. Other trademarks are for informational purposes only and may be trademarks of their respective owners.ĪWARDS & REVIEWS: ‘Awards & Reviews’ content as seen on this site may be sourced from publications around the globe. AMD, the AMD Arrow logo, ATI, the ATI logo, AMD Athlon, AMD Turion, Radeon and combinations thereof are trademarks of Advanced Micro Devices, Inc. and other countries.Īdvanced Micro Devices, Inc. NVIDIA, the NVIDIA logo, GeForce, GeForce RTX, GeForce MAX-Q, GRID, SHIELD, Battery Boost, CUDA, FXAA, GameStream, G-Sync, NVLINK, ShadowPlay, SLI, TXAA, PhysX, GeForce Experience, GeForce NOW, Maxwell, Pascal and Turing are trademarks and/or registered trademarks of NVIDIA Corporation in the U.S. Smart Selection orders are subjected to Dell’s Standard Terms and Conditions of Sale that are available at TRADEMARKS: Celeron, Intel, the Intel logo, Intel Atom, Intel Core, Intel Inside, the Intel Inside logo, Intel vPro, Intel Evo, Intel Optane, Intel Xeon Phi, Iris, Itanium, MAX, Pentium, and Xeon are trademarks of Intel Corporation or its subsidiaries. SMART SELECTION (In stock & ready to ship): 3 business days delivery within Singapore (depending on stock availability) from order confirmation & upon payment clearance. Customer may be required to return unit to Dell. CompleteCover excludes theft, loss, and damage due to fire, intentional damage, acts of God or natural disasters, animals, pets or pests. ĬOMPLETECOVER: CompleteCover service is available for personal computers, Axim PDAs, Dell branded projectors and LCD TV. Defective unit must be returned or paid for. Service timing dependent upon time of day call placed to Dell. Subject to parts availability, geographical restrictions (on site and/or next business day service not available in some locations) and terms of service contract. ONSITE SERVICE : Technician, replacement part or unit (depending on service contract) will be dispatched if necessary following phone-based troubleshooting. MISTAKES: While all efforts are made to check pricing and other errors, inadvertent errors do occur from time to time and Dell reserves the right to decline orders arising from such errors. Choose carefully, as order cancellation rights are limited and additional costs may apply. RETURNS POLICY: Dell’s “Returns Policy” found at //to all sales. If you have contractual terms with Dell that refer to list pricing, please contact your Dell sales representative to obtain information about Dell’s list pricing. Any promotional savings listed on this site are referenced off of a previous online price for the same product or service. No discounts apply to Dell’s online pricing other than the savings listed on this site. ![]() Pricing: The pricing available on this site is Dell’s pricing for online purchases only. Dell cannot guarantee that promotions and prices listed online will be available to purchase by telephone. Promotional deals apply to maximum order size of 10 desktop or laptop systems. **Dell's Terms and Conditions: apply to all sales available on request or at "Terms and Conditions of Sale" located at the bottom of our homepage at: Prices and specifications are correct at date of publication but subject to availability or change without notice. Energy, Climate Action & Sustainability. ![]() Your access (7 days or 30 days) starts when you have activated your license key and the hack is up running on your PC. #RAZE 3 HACKED CHEATS ADD STARS LICENSE KEY# This is to ensure that no customer will lose time if problems occur when they inject the hack for the first time.Ģ. Unlike other providers, we do offer support every time needed! We simply wanna help you get started successfully, so we can be sure to keep you as a happy customer.ģ. We provide the industry's safest hacks, period. 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If you are a veteran gamer who spends most of the day gaming and are not into those childish basic games, this is the best choice for you to play. The story is the aftermath of a prison break in Croatia and with 100 other survivors and has several game modes like an open world, team deathmatch, special events, and whatnot. This game is not only about killing and survival but has much more to it like vital stats of your player, maintaining their diet, and much more. Scum is the game for you if you are looking for something to keep you hooked all day and the first look on this game makes you feel that this is for the pros. The graphics are close to reality and animations are smooth creating a flawless overall gaming experience for you. Audio team has done a splendid job as well and came up with pretty immersive audio and sound effects are not lousy at any point from the rustling of wind through the grass to footsteps and sound effects of weapons, everything is well taken care of. 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O Battle Royale mode: The game has Battle Royale mode for you to enjoy it when you want a break from your progress in story mode and you can compete against other fugitives from the prison to be the last man surviving and win the game. ![]() O Team Death Match: Developers of Scum introduced Team DeathMatch mode for the players to compete against each other and test their skills in their favorite game.
Barb was the quintessential hostess and enjoyed appetizer nights at Applebee’s with friends, having good food, good conversation and a good “SoCo Manhattan on the rocks” with friends. She enjoyed this immensely and retired from this position with many happy memories and friends. After Matthew began elementary school, Barb began working at Community College of Allegheny County - South Campus (CCAC) as an administrative assistant to the athletic department. In September of 1970, the family moved to their final home in West Mifflin. With another job change, Barb, George and family moved to Troy, Mich., and with that change brought a new addition, the final addition to the family, Jon Matthew. In 1965, Barb and George moved to Washington, Pa., and their second child, Mari Michele, was born and Barb became the homemaker, par excellence, taking care of two children and the house and meeting friends that became family to this day. It was during this time that George and Barbara welcomed their first child, George Michael, in 1958. She met and married George Tzanakis in 1957 and the couple moved to Morgantown, W.Va., so that George could complete his degree from WVU with Barb working for Olin Mathison. She didn’t complete this, electing to come home to West Virginia to assist her mother and work for Sterling Faucet. After high school, Barbara attended flight attendant training school for Capitol Airlines in busy New York City. She graduated from Magnolia High School in Paden City, W.Va., in 1951 with her favorite classes being music and band. ![]() Barb, as she was more commonly known, was born July 28, 1933, in New Martinsville, W.Va., the youngest of two children born to Mary G. Barbara Ann Bland Tzanakis, passed away on Friday, March 17, 2023. When the primary light source, whether natural or artificial, is located behind the subject or in the background of a scene. The background provides context for the location of a photo, but it can also be blurred using a shallow depth of field to force a viewer to focus on the subject, something often done in portrait photography.īacklight. Any part of a scene that is behind the main subject, located at a farther distance than the subject from the camera. This gives the photographer more control over the photography process as different fingers will be responsible for exposing photos and autofocusing.īackground. A camera technique in which the autofocus function is moved from the shutter button to a button on the back of the camera. with phase or contract detection), or in a hybrid way through a variety of means, but generally involving a sensor, controller, and motor.īack Button Focus. A system in a camera that automatically focuses a lens on a selected point or area within a scene. Advancements in camera, computing, and telescopic technologies and the accompanying reduction in prices have opened the door to astronomical photos that were impossible just years ago, leading to an explosion in highly-detailed space photos from amateur astronomers and photographers.Īutofocus. Astronomical photography has to do with shooting photos of the night sky or anything found within it, including space objects and events. Typically found in higher-end camera lenses geared toward professional photographers.Īstrophotography. Compared to a traditional non-aspheric lens, the more complex shape of aspherical lenses allows light rays to more precisely converge onto a single focal point, reducing various types of optical aberrations. A type of optical lens in which the surface curves are not portions of a sphere. Common aspect ratios found in film and digital photography include 4:3, 3:2, 16:9, 5:3, 5:4, and 1:1.Īspherical Lens. Typically expressed as the two numbers separated by a colon. The ratio of an image’s width compared to its height. In 1974, ASA and DIN were combined into the ISO standards used by photographers today.Īspect Ratio. The private non-profit organization has since been renamed to American National Standards Institute (ANSI). The standards body that defined the ASA system for rating the speed sensitivity of photographic emulsions. Short for American Standards Association. Can refer to data storage technologies for digital images or paper, ink, and storage qualities for photographic prints.ĪSA. The quality and ability of a photo to remain unchanged in appearance for an extended period of time. Not commonly found in modern digital cameras, APS-H has a crop factor of about 1.25x or 1.3x compared to standard 35mm film.Īrchival. It measures 30.2×16.7mm with an aspect ratio of 16:9. Advanced Photo System type-H is a format for digital sensors that is based on the dimensions of Advanced Photo System (APS) film negative in its High Definition (H) format. Commonly found in digital cameras, the format is smaller than standard 35mm film, so it is known as a “cropped frame” sensor, usually with a crop factor of 1.5x or 1.6x.ĪPS-H. It measures 25.1×16.7mm with an aspect ratio of 3:2. Advanced Photo System type-C is a format for digital image sensors that is roughly the same dimensions as the Advanced Photo System (APS) film negative in its Classic (C) format. While APEX failed to become a fundamental standard in the camera industry, its use of Av and Tv to refer to aperture and shutter speed live on in modern cameras.ĪPS-C. A system for simple exposure computation first proposed in the 1960 ASA standard regarding monochrome film speed. Short for Additive System of Photographic Exposure. ![]() A camera exposure mode in which the photographer sets the aperture and the camera automatically sets the shutter speed in order to achieve optimal exposure based on lighting conditions detected by the built-in light meter.ĪPEX. Usually measured and expressed as a number known as the f-number of f-stop.Īperture Priority. ![]() This is one of the fundamental settings for controlling exposure and a component of the Exposure Triangle. The opening of the diaphragm within a lens that light passes through on its way into a camera. This can include both natural light from the Sun as well as artificial light already illuminating a location.Īngle of View (AOV). Any light in a scene that the photographer did not introduce artificially. Autofocus lock is a camera feature that allows a photographer to freeze the current focus point of the lens, enabling them to shoot a photo at any time independent of whether the camera determines it has achieved correct focus.Īmbient Light. ![]() Consultation services to assess individual fitness levels.Live-streamed fitness classes during the COVID-19 pandemic.Text-based alerts and emails with reminders to get people moving during the workday.However, in the past, we have offered the following services: Over time, our efforts evolved into a widespread campaign featuring a range of in-person and virtual exercise opportunities to support every fitness level and goal.īe Fit Pitt is not active at this time. We started with the simple goal of getting faculty and staff at the University to move more during the workday. The effort is led by our faculty and Graduate Student Assistants. ![]() The Be Fit Pitt initiative is based in the Healthy Lifestyle Institute at the University of Pittsburgh School of Education. Programming is not offered at this time ** History If you like a good "stars aligning" story, ask her what led her to take that leap.** Be Fit Pitt is no longer active. Five years ago, she left her beloved Studio Be in Maine to open Be Fit Co. In recent years her studies and practice have led her to leave the clinical setting in favor of a more relaxed and creative environment. You name it, and we can be affected by it. Specifically, how we are affected by internal and external forces like gravity, mass and momentum, pain, joy, trauma, injury, receptive motions. She has spent the last 25 years studying the art and science of the human body. You can watch a sample of talks given at the Gray Institute here. She enjoys public speaking to engage audiences in the nuances of movement, mindset, and behavior as an alternative to pills and procedures.įollowing her curiosities has led her to pursue local and national teaching opportunities. In partnership with Solve Global, she identifies areas of risk in the workplace and provides measurable solutions for reducing spending and improving outcomes and culture. Robin is an institutional health consultant, assessing past and current spending on musculoskeletal injuries - the highest cost in healthcare. Home Base is a Red Sox Foundation and Massachusetts General Hospital Program dedicated to healing the invisible wounds for Veterans of all eras, Service Members, Military Families, and Families of the Fallen through world-class clinical care, wellness, education, and research.Īt Home Base, Robin analyzed the existing program and recommended new ways to better serve more Veterans and Families in their Warrier Health and Fitness program in Boston and South West Florida. In 2018-2019 she was hired as a special consultant for Home Base Veteran and Family Care. Robin has a particular interest in Veteran and Family care. She went on to become a five-year member of the faculty - teaching movement and health practitioners from around the world. ![]() In 2010, she earned the distinction of Fellow of Applied Functional Science with the prestigious Gray Institute. She credits this diversity in finding common threads and practical solutions for a broad range of clients. 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Host 192.168.1.4 is not allowed to connect to this mysql server ![]() You can also validate this by doing telnet to 3306 mysql port as shown below, which will also give the same “host is not allowed to connect to this mysql server” error message as shown below. If you try to connect to a remote MySQL database from your client system, you will get “ ERROR 1130: Host is not allowed to connect to this MySQL server” message as shown below.ĮRROR 1130: Host '192.168.1.4' is not allowed to connect to this MySQL server Once you get in mysql just press ctrl + L and you will clear the screen.By default, MySQL does not allow remote clients to connect to the MySQL database. You can add more arguments in there if you want. It is intended for mission-critical, heavy-load production systems and mass-deployed software. MySQL is ideal for both small and large applications. MySQL is a fast, multi-threaded, multi-user, and robust SQL database server. 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Once you are done installing it, you should add the bin folder from cygwin in your PATH Environmental Variables(The above video explains that as well) Make sure when you select the packages that you want to install includes Mintt (it is basically a better shell or cmd) and mysql client package. It explains very easily how to install cygwin. Installed Cygwin (Go here) It is pretty straight forward to install. Full MySQL Support Sequel Pro is a fast, easy-to-use Mac database management application for working with MySQL databases. The mysql clients purpose is to allow you. The mysql server is used to persist the data and provide a query interface for it (SQL). You can use the mysql client to send commands to any mysql server on a remote computer or your own. The windows console (cmd) is just not worth using for anything other than some simple commands. The mysql server package will install the mysql database server which you can interact with using a mysql client. 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